22 days in Cuba, Guatemala & Colombia Itinerary

22 days in Cuba, Guatemala & Colombia Itinerary

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Route & dates

Start: Lisbon, Portugal
+2
Fly + Foot + Bus:  16 h 45 min
1
Varadero, Cuba
— 1 night
Drive:  4 h
2
Trinidad, Cuba
— 2 nights
Drive:  4 h
3
Cayo Guillermo, Cuba
— 1 night
Drive + Bus:  8 h 30 min
4
Cayo Largo, Cuba
— 1 night
Fly:  1 h 15 min
5
Havana, Cuba
— 3 nights
+4
Fly + Foot + Bus + Foot + Bus:  8 h 30 min
6
Antigua, Guatemala
— 2 nights
+4
Bus + Foot + Bus + Foot + Fly:  8 h 15 min
7
Bogota, Colombia
— 1 night
Fly + Bus:  2 h 15 min
8
Cali, Colombia
— 2 nights
Fly:  3 h
9
San Andres Island, Colombia
— 2 nights
Fly:  3 h 15 min
10
Cartagena, Colombia
— 3 nights
Fly + Train:  13 h 15 min
End: Dusseldorf, Germany

1
night
Varadero, Cuba

Varadero ©
One of the largest resort towns in the Caribbean, Varadero boasts a 20 km (12 mi) long stretch of sand, lined with hotels and all-inclusive resorts.
On the 2nd (Tue), take in the architecture and atmosphere at Iglesia Santa Elvira, tour the pleasant surroundings at Varadero Beach, examine the collection at House of Rum, delve into the distant past at Cueva de Ambrosio, then look for all kinds of wild species at Varahicacos Ecological Reserve, and finally stroll through Cayos Blancos.

To find more things to do, reviews, ratings, and more tourist information, read our Varadero trip planning website.

Lisbon, Portugal to Varadero is an approximately 16- hour combination of flight and bus. You can also do a combination of flight, train, and bus; or do a combination of train, flight, and bus. The time zone difference moving from Western European Standard Time (WET) to Cuba Standard Time (CST) is minus 5 hours. Traveling from Lisbon in June, expect Varadero to be somewhat warmer, temps between 36°C and 25°C. Cap off your sightseeing on the 2nd (Tue) early enough to go by car to Trinidad.

Things to do in Varadero

Parks Beaches Outdoors

Side Trip

Cayos Blancos
Find places to stay Jun 1 — 2:
Highlights from your plan
Varadero Beach ©
Varadero Beach
Cayos Blancos ©
Cayos Blancos
Varahicacos Ecological Reserve ©
Varahicacos Ecological Reserve

2
nights
Trinidad, Cuba

Trinidad ©
Built on sugar and seemingly preserved in molasses, the town of Trinidad attracts visitors with its well-aged 19th century architecture and rustic charm, showcasing the sounds, scents, and sights of days gone by.
Kick off your visit on the 3rd (Wed): examine the collection at Museo de Historia Municipal, don't miss a visit to Plaza Mayor, examine the collection at Romance Museum, then make a trip to Cerro de la Vigia, then take your sightseeing to a higher altitude at Topes de Collantes, and finally admire the sheer force of Salto del Caburni. On your second day here, tour the pleasant surroundings at Playa Maria Aguilar, kick back and relax at Ancon Beach, then take in the architecture and atmosphere at Church of the Holy Trinity, then identify plant and animal life at Valle de los Ingenios, and finally don't miss a visit to Iznaga Tower.

To find more things to do, traveler tips, reviews, and tourist information, use the Trinidad day trip app.

Traveling by car from Varadero to Trinidad takes 4 hours. Alternatively, you can take a bus. Expect somewhat warmer evenings in Trinidad when traveling from Varadero in June, with lows around 36°C. Wrap up your sightseeing on the 4th (Thu) to allow time to drive to Cayo Guillermo.

Things to do in Trinidad

Parks Beaches Outdoors

Side Trips

Topes de Collantes, Playa Maria Aguilar
Find places to stay Jun 2 — 4:
Highlights from your plan
Topes de Collantes ©
Topes de Collantes
Plaza Mayor ©
Plaza Mayor
Ancon Beach ©
Ancon Beach

1
night
Cayo Guillermo, Cuba

Cayo Guillermo
A kay of the Jardines del Rey archipelago, Cayo Guillermo has become a popular international tourist destination, buoyed by the construction of luxury all inclusive resorts that dot the paradisal island.
Kick off your visit on the 5th (Fri): step off the mainland to explore Cayo Media Luna, then tour the pleasant surroundings at Cayo Guillermo, and then kick back and relax at Playa Pilar.

To find reviews, ratings, other places to visit, and more tourist information, go to the Cayo Guillermo trip builder app.

Drive from Trinidad to Cayo Guillermo in 4 hours. Alternatively, you can do a combination of bus, train, and taxi; or do a combination of bus and car. Traveling from Trinidad in June, expect slightly colder with lows of 28°C in Cayo Guillermo. Wrap up your sightseeing by early afternoon on the 5th (Fri) to allow time for travel to Cayo Largo.

Things to do in Cayo Guillermo

Parks Beaches Outdoors
Find places to stay Jun 4 — 5:
Highlights from your plan
Playa Pilar
Playa Pilar
Cayo Guillermo ©
Cayo Guillermo
Cayo Media Luna ©
Cayo Media Luna

1
night
Cayo Largo, Cuba

Cayo Largo ©
The stress of modern life feels a million miles away when you holiday on Cayo Largo, a small and unspoiled resort island off the coast of Cuba.
On the 6th (Sat), enjoy the sand and surf at Sirena Beach, then look for all kinds of wild species at Sea Turtle Hatchery, and then kick back and relax at Playa Paraiso. Get ready for a full day of sightseeing on the 7th (Sun): admire the verdant scenery at Valle de Vinales, then take in nature's colorful creations at Jardin Botanico de Vinales, then identify plant and animal life at El Torreon Nursery, and finally stroll through Punta Mal Tiempo.

To find maps, where to stay, traveler tips, and other tourist information, go to the Cayo Largo road trip planning site.

Do a combination of car and bus from Cayo Guillermo to Cayo Largo in 11.5 hours. Expect a daytime high around 36°C in June, and nighttime lows around 28°C. Finish your sightseeing early on the 7th (Sun) to allow enough time to travel to Havana.

Things to do in Cayo Largo

Parks Beaches Outdoors

Side Trip

Vinales
Find places to stay Jun 5 — 7:
Highlights from your plan
Playa Paraiso ©
Playa Paraiso
Sirena Beach ©
Sirena Beach
Punta Mal Tiempo ©
Punta Mal Tiempo

3
nights
Havana, Cuba

Cuba's capital and major commercial center, Havana manages to be very old and very modern at the same time.
Get outdoors at Nature & Wildlife Tours and CicloCuba. Your inner history buff will appreciate Old Havana and Malecón of Havana. There's much more to do: steep yourself in history at El Morro, visit Christopher Columbus Cemetery (Cemetario de Colon), don't miss a visit to Plaza de la Catedral, and take an in-depth tour of Museum of the Revolution (Museo de la Revolucion).

To see other places to visit, maps, and tourist information, read our Havana visit planner.

You can fly from Cayo Largo to Havana in 4 hours. Alternatively, you can take a bus; or do a combination of flight, bus, and train. June in Havana sees daily highs of 36°C and lows of 26°C at night. Wrap up your sightseeing on the 10th (Wed) early enough to travel to Antigua.

Things to do in Havana

Historic Sites Museums Outdoors
Find places to stay Jun 7 — 10:
Highlights from your plan
Nature & Wildlife Tours
Malecón of Havana ©
Malecón of Havana
Old Havana ©
Old Havana

2
nights
Antigua, Guatemala

Antigua ©
The former capital of Guatemala and a World Heritage Site, Antigua retains its colonial charm and remains one of the most visited destinations in the country.
On the 11th (Thu), explore the ancient world of Arco de Santa Catalina, make a trip to Cerro de la Cruz, then take in the spiritual surroundings of Catedral Metropolitana, then contemplate the long history of Palacio Nacional, and finally contemplate in the serene atmosphere at Iglesia de San Francisco. Here are some ideas for day two: contemplate the geological forces at Volcan de Agua, contemplate the long history of Casa Popenoe, take an in-depth tour of Casa Santo Domingo Museums, then explore the ancient world of Convento de las Capuchinas, and finally pause for some serene contemplation at Iglesia de La Merced.

For maps, other places to visit, photos, and tourist information, use the Antigua trip itinerary builder site.

You can do a combination of flight and bus from Havana to Antigua in 8.5 hours. Other options are to do a combination of flight and shuttle; or do a combination of train, bus, and flight. The time zone difference when traveling from Havana to Antigua is minus 1 hour. Traveling from Havana in June, expect Antigua to be slightly colder, temps between 29°C and 19°C. Wrap up your sightseeing on the 12th (Fri) early enough to travel to Bogota.

Things to do in Antigua

Historic Sites Museums Nature

Side Trip

Guatemala City
Find places to stay Jun 10 — 12:
Highlights from your plan
Iglesia de La Merced ©
Iglesia de La Merced
Convento de las Capuchinas ©
Convento de las Capuchinas
Volcan de Agua ©
Volcan de Agua

1
night
Bogota, Colombia

Bogota ©
Colombia's heart and soul, Bogota has earned the nickname "Athens of South America" thanks to its abundance of universities, libraries, and lower-level schools.
Start off your visit on the 13th (Sat): pause for some serene contemplation at Catedral de Sal de Zipaquira and then explore the world behind art at Museo Botero del Banco de la Republica. On the next day, take in the spiritual surroundings of Basilica of Our Lord of Miracles of Buga, then contemplate the long history of Bolivar Square, then see the interesting displays at Gold Museum (Museo del Oro), and finally take your sightseeing to a higher altitude at Monserrate.

To see traveler tips, more things to do, ratings, and more tourist information, use the Bogota trip planner.

Getting from Antigua to Bogota by combination of bus and flight takes about 8.5 hours. Other options: do a combination of shuttle and flight; or do a combination of bus and flight. The time zone difference when traveling from Antigua to Bogota is 1 hour. Prepare for a bit cooler weather when traveling from Antigua in June: high temperatures in Bogota hover around 22°C and lows are around 11°C. Wrap up your sightseeing on the 14th (Sun) early enough to travel to Cali.

Things to do in Bogota

Historic Sites Museums Nature

Side Trips

Catedral de Sal de Zipaquira, Basilica of Our Lord of Miracles of Buga
Find places to stay Jun 12 — 14:
Highlights from your plan
Catedral de Sal de Zipaquira ©
Catedral de Sal de Zipaquira
Gold Museum (Museo del Oro) ©
Gold Museum (Museo del Oro)
Museo Botero del Banco de la Republica ©
Museo Botero del Banco de la Republica

2
nights
Cali, Colombia

Cali ©
Learning how to salsa may be the most popular thing to do in Cali, but this giant city in southwestern Colombia represents more than just the "Salsa Capital of the World." Home to over 2 million people, thriving Cali serves as a major commercial and industrial center in South America, boasting the fastest-growing economy in Colombia.
On the 15th (Mon), appreciate the extensive heritage of Camino Real, then trek along Picoloro Ecoturismo, then see the interesting displays at Museo del Oro Calima, and finally appreciate the extensive heritage of Iglesia de San Antonio. On the 16th (Tue), you'll have a packed day of sightseeing: see the interesting displays at MUSA Museo Arqueologico, see the interesting displays at Caliwood Museo de la Cinematografia, take in the architecture and atmosphere at Iglesia La Ermita, then see the interesting displays at Museo Aereo Fenix, and finally take in the architecture and atmosphere at Catedral de Nuestra Senora del Rosario del Palmar.

To find where to stay, ratings, and other tourist information, refer to the Cali road trip planning website.

Do a combination of flight and bus from Bogota to Cali in 2.5 hours. Alternatively, you can do a combination of taxi and bus; or drive. When traveling from Bogota in June, plan for much hotter days and somewhat warmer nights in Cali: temperatures range from 36°C by day to 22°C at night. Finish up your sightseeing early on the 16th (Tue) so you can travel to San Andres Island.

Things to do in Cali

Historic Sites Museums Tours

Side Trips

Camino Real, Catedral de Nuestra Senora del Rosario del Palmar
Find places to stay Jun 14 — 16:
Highlights from your plan
Picoloro Ecoturismo ©
Picoloro Ecoturismo
Museo Aereo Fenix ©
Museo Aereo Fenix
Camino Real ©
Camino Real

2
nights
San Andres Island, Colombia

San Andres Island ©
The coral San Andres Island boasts a rich colonial history, exotic beaches, and a laidback, tropical lifestyle.
On the 17th (Wed), kick back and relax at Playa Charquitos, enjoy the sand and surf at Playa de San Luis, identify plant and animal life at La Piscinita, then look for all kinds of wild species at West View, and finally explore the striking landscape at Hoyo Soplador. On the next day, step off the mainland to explore Johnny Cay, enjoy the sand and surf at Playa de Spratt Bight, then discover the deep blue sea with a scuba or snorkeling tour, and finally look for all kinds of wild species at Cayo El Acuario.

To see where to stay, photos, other places to visit, and other tourist information, you can read our San Andres Island trip planner.

Fly from Cali to San Andres Island in 3 hours. Traveling from Cali in June, expect a bit warmer with lows of 30°C in San Andres Island. Wrap up your sightseeing on the 18th (Thu) to allow time to travel to Cartagena.

Things to do in San Andres Island

Parks Wildlife Outdoors
Find places to stay Jun 16 — 18:
Highlights from your plan
La Piscinita ©
La Piscinita
Cayo El Acuario ©
Cayo El Acuario
West View
West View

3
nights
Cartagena, Colombia

Cartagena ©
The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.
Start off your visit on the 19th (Fri): see some colorful creatures with a scuba or snorkeling tour, then get engrossed in the history at Museo del Oro Zenu, then make a trip to Castillo de San Felipe de Barajas, and finally go for a walk through Plazoleta de Blas de Lezo. Get ready for a full day of sightseeing on the 20th (Sat): take in the spiritual surroundings of Convent of Santa Cruz de la Popa, steep yourself in history at Plaza Santo Domingo, then take in the architecture and atmosphere at Sanctuary of Saint Peter Claver, and finally steep yourself in history at Walled City of Cartagena.

To find ratings, photos, and more tourist information, read our Cartagena trip planner.

Traveling by flight from San Andres Island to Cartagena takes 3.5 hours. Expect a daytime high around 38°C in June, and nighttime lows around 30°C. Wrap up your sightseeing on the 21st (Sun) to allow time to travel back home.

Things to do in Cartagena

Historic Sites Tours Wildlife
Find places to stay Jun 18 — 21:
Highlights from your plan
Walled City of Cartagena ©
Walled City of Cartagena
Castillo de San Felipe de Barajas ©
Castillo de San Felipe de Barajas
Plaza Santo Domingo ©
Plaza Santo Domingo

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