23 days in South America & Central America Itinerary

23 days in South America & Central America Itinerary

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Route & dates

23 days in South America & Central America Itinerary

Start: Miami, United States
Fly:  7 h
1
Cali, Colombia
— 3 nights
Fly:  4 h 30 min
2
Guayaquil, Ecuador
— 3 nights
Fly + Taxi:  1 h 45 min
3
Quito, Ecuador
— 2 nights
Fly:  7 h 15 min
4
La Paz, Bolivia
— 4 nights
Fly:  3 h 15 min
5
Santa Cruz, Bolivia
— 2 nights
Bus + Fly:  1 h 30 min
6
Asuncion, Paraguay
— 2 nights
Fly:  6 h 45 min
7
Panama City, Panama
— 5 nights
Fly + Bus:  8 h 30 min
End: New York City, United States

3
nights
Cali, Colombia

Cali ©
Learning how to salsa may be the most popular thing to do in Cali, but this giant city in southwestern Colombia represents more than just the "Salsa Capital of the World." Home to over 2 million people, thriving Cali serves as a major commercial and industrial center in South America, boasting the fastest-growing economy in Colombia.
Cali is known for zoos & aquariums, historic sites, and museums. Your plan includes some of its best attractions: see the interesting displays at Museo Aereo Fenix, get to know the resident critters at Zoologico de Cali, make a trip to Mirador Sebastian Belalcazar, and explore the world behind art at Museo de Arte Colonial y Religioso La Merced.

Plan my day in Cali using traveler tips and tourist information provided by Inspirock.

Miami, USA to Cali is an approximately 7- hour flight. You can also do a combination of train and flight; or do a combination of flight and bus. Traveling from Miami in August, expect little chillier with lows of 66°F in Cali. Finish your sightseeing early on the 18th (Tue) so you can travel to Quito.

Things to do in Cali

Parks Museums Wildlife
Find places to stay Aug 15 — 18:
Highlights from your plan
Museo Aereo Fenix ©
Museo Aereo Fenix
Zoologico de Cali ©
Zoologico de Cali
Caliwood Museo de la Cinematografia ©
Caliwood Museo de la Cinematografia

3
nights
Guayaquil, Ecuador

Guayaquil ©
Hills dotted with colorful houses and waterfront promenades typify Guayaquil, Ecuador's largest city and commercial center.
Guayaquil is known for historic sites, parks, and shopping. Your plan includes some of its best attractions: take in the waterfront at Malecon 2000, visit a coastal fixture at El Faro de Guayaquil, admire the striking features of Torre Morisca, and take in the architecture and atmosphere at Iglesia de La Merced.

For other places to visit, photos, where to stay, and other tourist information, read Guayaquil online trip maker.

Traveling by flight from Cali to Guayaquil takes 4.5 hours. Alternatively, you can drive; or take a bus. In August, plan for daily highs up to 86°F, and evening lows to 70°F. Wrap up your sightseeing on the 21st (Fri) early enough to travel to Quito.

Things to do in Guayaquil

Historic Sites Neighborhoods Parks
Find places to stay Aug 18 — 21:
Highlights from your plan
Guayaquil Historical Park ©
Guayaquil Historical Park
Malecon 2000 ©
Malecon 2000
Las Penas ©
Las Penas

2
nights
Quito, Ecuador

Quito ©
High in the Andean foothills, Quito remains one of the world's most photogenic capital cities, featuring two dramatic mountain ranges as its backdrop.
On the 22nd (Sat), contemplate in the serene atmosphere at Basilica del Voto Nacional, admire the landmark architecture of Fundacion Iglesia de la Compania, then take an in-depth tour of Museo Templo del Sol Pintor Ortega Maila, then don't miss a visit to Mitad Del Mundo, and finally look for gifts at La Mundial Custom Boots. On the 23rd (Sun), you'll have a packed day of sightseeing: take an in-depth tour of Museum of Maria Augusta Urrutia (La Casa Museo Maria Augusta Urrutia), don't miss a visit to El Panecillo, then admire the landmark architecture of Iglesia y Convento de San Francisco, and finally get to know the fascinating history of Quito Old Town.

To see photos, other places to visit, where to stay, and more tourist information, you can read our Quito trip maker.

You can do a combination of flight and taxi from Guayaquil to Quito in 2 hours. Other options are to drive; or do a combination of taxi and bus. Traveling from Guayaquil in August, things will get little chillier in Quito: highs are around 74°F and lows about 56°F. Wrap up your sightseeing on the 23rd (Sun) early enough to travel to La Paz.

Things to do in Quito

Historic Sites Museums Shopping
Find places to stay Aug 21 — 23:
Highlights from your plan
Fundacion Iglesia de la Compania ©
Fundacion Iglesia de la Compania
Quito Old Town ©
Quito Old Town

4
nights
La Paz, Bolivia

Take a moment to catch your breath as you commence your holiday in La Paz.
Step out of La Paz to go to Tiahuanaco and see Puma Punku, which is approximately 1h 10 min away. Spend the 25th (Tue) exploring the striking scenery along WMDR Yungas Road. There's lots more to do: get the adrenaline pumping with an extreme tour, put a fun spin on your tour with Atrapados Escape Rooms, examine the collection at National Museum of Ethnography and Folklore, and delve into the distant past at Tiwanaku.

To find traveler tips, photos, maps, and other tourist information, use the La Paz trip itinerary planning website.

You can fly from Quito to La Paz in 7.5 hours. Other options are to drive; or do a combination of bus and car. You'll lose 1 hour traveling from Quito to La Paz due to the time zone difference. Expect little chillier weather when traveling from Quito in August: highs in La Paz hover around 60°F, while lows dip to 26°F. Finish up your sightseeing early on the 28th (Fri) so you can travel to Santa Cruz.

Things to do in La Paz

Outdoors Tours Scenic Drive

Side Trip

Puma Punku
Find places to stay Aug 23 — 28:
Highlights from your plan
Adrenaline & Extreme Tours
Mi Teleferico ©
Mi Teleferico
WMDR Yungas Road ©
WMDR Yungas Road

2
nights
Santa Cruz, Bolivia

Santa Cruz ©
More populous than the capital and La Paz, and one of the fastest-growing cities in the world, Santa Cruz has become a thriving commercial center, yet retained some of the trappings of tradition.
Kick off your visit on the 29th (Sat): buy something for everyone on your list at Ventura mall, admire the natural beauty at Guembe, and then admire the masterpieces at Museo Artecampo. Here are some ideas for day two: explore the striking landscape of Amboro National Park and then contemplate in the serene atmosphere at Catedral de Santa Cruz.

To find traveler tips and more tourist information, read Santa Cruz journey planner.

Fly from La Paz to Santa Cruz in 3.5 hours. Alternatively, you can drive; or take a bus. Traveling from La Paz in August, expect Santa Cruz to be much hotter, temps between 83°F and 64°F. Finish your sightseeing early on the 30th (Sun) to allow enough time to travel to Asuncion.

Things to do in Santa Cruz

Parks Nature Historic Sites

Side Trip

Amboro National Park
Find places to stay Aug 28 — 30:
Highlights from your plan
Guembe ©
Guembe
Catedral de Santa Cruz ©
Catedral de Santa Cruz
Ventura mall ©
Ventura mall

2
nights
Asuncion, Paraguay

Asuncion ©
Paraguay's capital and economic center, Asuncion ranks among the youngest cities on the continent, with more than half of its residents under 30 years of age.
Start off your visit on the 31st (Mon): admire the landmark architecture of Banco Nacional de Fomento, admire the landmark architecture of The National Pantheon of Heroes and Oratory of the Virgin Our Lady Saint Mary of the Asuncion, then ponder the world of politics at Palacio de López, and finally contemplate the long history of Casa de la Independencia. Get ready for a full day of sightseeing on the next day: shop like a local with Shopping del Sol, then browse the range of quality goods at Paseo La Galeria, and then don't miss a visit to Costanera de Asuncion.

To see where to stay, traveler tips, more things to do, and tourist information, go to the Asuncion online attractions planner.

You can do a combination of bus and flight from Santa Cruz to Asuncion in 1.5 hours. Other options are to drive; or take a bus. Plan for a bit cooler nights when traveling from Santa Cruz in August since evenings lows in Asuncion dip to 58°F. Finish your sightseeing early on the 1st (Tue) to allow enough time to travel to Panama City.

Things to do in Asuncion

Shopping Historic Sites Museums
Find places to stay Aug 30 — Sep 1:
Highlights from your plan
Shopping del Sol ©
Shopping del Sol
Casa de la Independencia ©
Casa de la Independencia
Palacio de López ©
Palacio de López

5
nights
Panama City, Panama

Panama City ©
Arguably the most modern of Central American cities, Panama City boasts a shimmering skyline of glass skyscrapers.
Panama City is known for historic sites, shopping, and museums. Your plan includes some of its best attractions: make a trip to Panama Canal, delve into the distant past at Panama La Vieja, appreciate the extensive heritage of Avenida Balboa, and take a stroll through Casco Viejo.

To see maps, where to stay, photos, and other tourist information, you can read our Panama City itinerary planning site.

You can fly from Asuncion to Panama City in 7 hours. Traveling from Asuncion to Panama City, you'll gain 1 hour due to the time zone difference. Traveling from Asuncion in September, expect a bit warmer with lows of 76°F in Panama City. Wrap up your sightseeing by early afternoon on the 6th (Sun) to allow time for travel back home.

Things to do in Panama City

Historic Sites Neighborhoods Museums
Find places to stay Sep 1 — 6:
Highlights from your plan
Panama Canal ©
Panama Canal
Amador Causeway (Calzada de Amador) ©
Casco Viejo ©
Casco Viejo

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