26 days in Greece, Italy & Spain Itinerary

26 days in Greece, Italy & Spain Itinerary

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Route & dates

26 days in Greece, Italy & Spain Itinerary

Start: San Francisco, United States
Fly + Drive:  24 h
1
Kalymnos, Greece
— 2 nights
Drive + Fly:  4 h 30 min
2
Athens, Greece
— 3 nights
Fly:  5 h
3
Rome, Italy
— 4 nights
Train:  1 h 45 min
4
Florence, Italy
— 4 nights
Train:  2 h 15 min
5
Venice, Italy
— 3 nights
Fly:  4 h 45 min
6
Barcelona, Spain
— 4 nights
Train:  2 h 45 min
7
Madrid, Spain
— 3 nights
Fly:  18 h 45 min
End: San Francisco, United States

2
nights
Kalymnos, Greece

Kalymnos ©
Start off your visit on the 21st (Fri): don't miss a visit to Neoklasiko Private Folklore and Historical Collections, make a trip to Agios Savvas Monastery, and then shake up your sightseeing with a climbing tour. Keep things going the next day: examine the collection at Sea World Museum Valsamidis, then don't miss a visit to N S Papachatzis Sponge Factory, then stroll through Platis Yialos Beach, and finally see the interesting displays at Archaeological Museum of Kalymnos.

For reviews, ratings, traveler tips, and more tourist information, refer to the Kalymnos sightseeing planner.

San Francisco, USA to Kalymnos is an approximately 24-hour flight. Due to the time zone difference, you'll lose 10 hours traveling from San Francisco to Kalymnos. Traveling from San Francisco in April, you can expect nighttime temperatures to be a bit warmer in Kalymnos, with lows of 55°F. Finish your sightseeing early on the 23rd (Sun) to allow enough time to travel to Athens.

Things to do in Kalymnos

Outdoors Beaches Tours
Find places to stay Apr 21 — 23:
Highlights from your plan
N S Papachatzis Sponge Factory ©
N S Papachatzis Sponge Factory

3
nights
Athens, Greece

Athens ©
One of the world's most ancient cities, Athens remains Europe's undisputed historical and cultural capital.
Athens is known for historic sites, museums, sightseeing, shopping, and nightlife. Your plan includes some of its best attractions: delve into the distant past at Acropolis of Athens, wander the streets of Plaka District, admire the masterpieces at Benaki Museum, and take in the awesome beauty at Mount Lycabettus.

To find more things to do, reviews, maps, and other tourist information, read our Athens trip builder.

Use the Route module to find suitable travel options from Kalymnos to Athens. In April, daytime highs in Athens are 69°F, while nighttime lows are 51°F. Wrap up your sightseeing on the 26th (Wed) early enough to travel to Rome.

Things to do in Athens

Historic Sites Museums Parks
Find places to stay Apr 23 — 26:
Highlights from your plan
Acropolis of Athens ©
Acropolis of Athens
Acropolis Museum ©
Acropolis Museum
Plaka ©
Plaka

4
nights
Rome, Italy

Rome ©
Aptly nicknamed the Eternal City, Rome is the birthplace of the Roman Empire, one of the world's greatest civilizations ever.
Rome is known for historic sites, sightseeing, museums, nightlife, and shopping. Your plan includes some of its best attractions: delve into the distant past at Colosseum, steep yourself in history at Palatine Hill, make a trip to Trevi Fountain, and admire the landmark architecture of Pantheon.

To find traveler tips, reviews, more things to do, and other tourist information, read Rome travel itinerary creator.

Fly from Athens to Rome in 5 hours. Alternatively, you can do a combination of ferry and car; or take a bus. The time zone changes from Eastern European Time to Central European Time, which is usually a -1 hour difference. Expect a daytime high around 68°F in April, and nighttime lows around 49°F. Finish up your sightseeing early on the 30th (Sun) so you can catch the train to Florence.

Things to do in Rome

Historic Sites Museums

Side Trip

Vatican City
Find places to stay Apr 26 — 30:
Highlights from your plan
Colosseum ©
Colosseum
Trevi Fountain ©
Trevi Fountain
Pantheon ©
Pantheon

4
nights
Florence, Italy

Florence ©
Considered a cultural, artistic, and architectural jewel of Italy, Florence is the birthplace of the Italian Renaissance.
Florence is known for sightseeing, museums, historic sites, shopping, and nightlife. Your plan includes some of its best attractions: examine the collection at Uffizi Gallery, take in the spiritual surroundings of Cathedral of Santa Maria del Fiore, admire the striking features of Campanile di Giotto, and take in nature's colorful creations at The Boboli Gardens.

For reviews, traveler tips, and more tourist information, you can read our Florence tour planner.

Traveling by train from Rome to Florence takes 2 hours. Alternatively, you can drive; or fly. Expect a daytime high around 68°F in April, and nighttime lows around 48°F. Cap off your sightseeing on the 4th (Thu) early enough to catch the train to Venice.

Things to do in Florence

Historic Sites Museums Parks
Find places to stay Apr 30 — May 4:
Highlights from your plan
Cathedral of Santa Maria del Fiore ©
Cathedral of Santa Maria del Fiore
Gallerie Degli Uffizi ©
Gallerie Degli Uffizi
Academy Of Florence Art Gallery ©
Academy Of Florence Art Gallery

3
nights
Venice, Italy

Venice ©
Virtually unchanged for the last six centuries, Venice is actually a group of islands made famous by a series of canals, bridges, monuments, piazzas, and narrow pedestrian lanes.
Explore the numerous day-trip ideas around Venice: Padua (Basilica di Sant’Antonio - Basilica del Santo & Scrovegni Chapel). The adventure continues: explore the activities along Canal Grande, contemplate the long history of Squero di San Trovaso, admire the masterpieces at Peggy Guggenheim Collection, and take in the views from Ponte di Rialto.

For ratings, other places to visit, more things to do, and tourist information, use the Venice custom trip planner.

Traveling by train from Florence to Venice takes 2.5 hours. Alternatively, you can drive; or fly. In May, daytime highs in Venice are 71°F, while nighttime lows are 56°F. Cap off your sightseeing on the 7th (Sun) early enough to travel to Barcelona.

Things to do in Venice

Historic Sites Museums Nature

Side Trip

Padua
Find places to stay May 4 — 7:
Highlights from your plan
Doge's Palace ©
Doge's Palace
Canal Grande ©
Canal Grande
Basilica di San Marco
Basilica di San Marco

4
nights
Barcelona, Spain

Barcelona ©
Barcelona, the country’s second-largest city, is a cosmopolitan urban center known for its throbbing youthful energy and stellar architecture.
Barcelona is known for sightseeing, parks, museums, nightlife, and shopping. Your plan includes some of its best attractions: pause for some serene contemplation at La Sagrada Familia, appreciate the history behind Casa Batlló, explore and take pictures at Camp Nou, and tour the pleasant surroundings at Park Güell.

To see other places to visit, photos, more things to do, and other tourist information, read Barcelona trip itinerary planner.

You can fly from Venice to Barcelona in 5 hours. Alternatively, you can drive; or take a train. In May, plan for daily highs up to 71°F, and evening lows to 58°F. Wrap up your sightseeing on the 11th (Thu) to allow time to take a train to Madrid.

Things to do in Barcelona

Historic Sites Neighborhoods Wildlife
Find places to stay May 7 — 11:
Highlights from your plan
Basilica of the Sagrada Familia ©
Basilica of the Sagrada Familia
Parc Guell ©
Parc Guell
Casa Batllo ©
Casa Batllo

3
nights
Madrid, Spain

Madrid ©
Madrid is known for its cultural and artistic heritage, lively nightlife, and a dynamic culinary scene.
Madrid is known for sightseeing, museums, parks, shopping, and nightlife. Your plan includes some of its best attractions: see the interesting displays at Museo Nacional del Prado, admire the natural beauty at Retiro Park (Parque del Retiro), hunt for treasures at Mercado San Miguel, and make a trip to Puerta del Sol.

To find other places to visit, where to stay, ratings, and more tourist information, you can read our Madrid vacation trip planner.

Take a train from Barcelona to Madrid in 3 hours. Alternatively, you can fly; or drive. Plan for slightly colder nights when traveling from Barcelona in May since evenings lows in Madrid dip to 52°F. Cap off your sightseeing on the 14th (Sun) early enough to travel back home.

Things to do in Madrid

Museums Historic Sites Parks
Find places to stay May 11 — 14:
Highlights from your plan
Prado National Museum ©
Prado National Museum
Parque del Retiro ©
Parque del Retiro
Royal Palace of Madrid ©
Royal Palace of Madrid

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