42 days in South America Itinerary

42 days in South America Itinerary

Created using Inspirock South America holiday planner

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Route & dates

1
San Andres Island, Colombia
— 2 nights
2
Bogota, Colombia
— 2 nights
3
Tayrona National Park, Colombia
— 2 nights
4
Cartagena, Colombia
— 2 nights
5
Margarita Island, Venezuela
— 6 nights
6
Coro, Venezuela
— 3 nights
7
Caracas, Venezuela
— 2 nights
8
Arequipa, Peru
— 2 nights
9
Maras, Peru
— 2 nights
10
Machu Picchu, Peru
— 2 nights
11
Cusco, Peru
— 2 nights
12
Lima, Peru
— 2 nights
13
Cuenca, Ecuador
— 2 nights
14
Quito, Ecuador
— 2 nights
15
Puerto Villamil, Ecuador
— 2 nights
16
Puerto Ayora, Ecuador
— 3 nights
17
Puerto Baquerizo Moreno, Ecuador
— 1 night

2
nights
San Andres Island, Colombia

San Andres Island ©
The coral San Andres Island boasts a rich colonial history, exotic beaches, and a laidback, tropical lifestyle.
Start off your visit on the 2nd (Fri): Head underground at Morgan's Cave, thenlook for all kinds of wild species at La Piscinita, and then see the vivid underwater world at West View. On the 3rd (Sat), you'll have a packed day of sightseeing: see the interesting displays at Parque Tematico El Pueblito Isleno San Andres, thenpause for some serene contemplation at Primera Iglesia Bautista, thenexplore the striking landscape at Hoyo Soplador, and finally identify plant and animal life at Cayo El Acuario.

To see ratings, traveler tips, other places to visit, and more tourist information, use the San Andres Island travel route builder app.

San Francisco, USA to San Andres Island is an approximately 16-hour flight. The time zone changes from Pacific Standard Time to Colombia Standard Time, which is usually a 3 hour difference. While traveling from San Francisco, expect somewhat warmer days and warmer nights in San Andres Island, ranging from highs of °F to lows of °F. Wrap up your sightseeing on the 3rd (Sat) to allow time to travel to Bogota.

Things to do in San Andres Island

Parks Wildlife Nature
Find places to stay Oct 1 — 3:
Highlights from your plan
La Piscinita ©
La Piscinita
Cayo El Acuario ©
Cayo El Acuario
West View
West View

2
nights
Bogota, Colombia

Bogota ©
Colombia's heart and soul, Bogota has earned the nickname "Athens of South America" thanks to its abundance of universities, libraries, and lower-level schools.
Start off your visit on the 4th (Sun): stroll through Monserrate, thenexamine the collection at Gold Museum (Museo del Oro), and then make a trip to Bolivar Square. Keep things going the next day: explore the world behind art at Museo Botero del Banco de la Republica and then pause for some serene contemplation at Catedral de Sal de Zipaquira.

To find ratings, traveler tips, photos, and more tourist information, read our Bogota trip builder tool.

Fly from San Andres Island to Bogota in 4 hours. Traveling from San Andres Island in October, things will get much colder in Bogota: highs are around °F and lows about °F. Wrap up your sightseeing on the 5th (Mon) early enough to travel to Tayrona National Park.

Things to do in Bogota

Museums Historic Sites Nature

Side Trip

Catedral de Sal de Zipaquira
Find places to stay Oct 3 — 5:
Highlights from your plan
Gold Museum (Museo del Oro) ©
Gold Museum (Museo del Oro)
Catedral de Sal de Zipaquira ©
Catedral de Sal de Zipaquira
Museo Botero del Banco de la Republica ©
Museo Botero del Banco de la Republica

2
nights
Tayrona National Park, Colombia

Tayrona National Park ©
On the 6th (Tue), explore the striking landscape of Parque Nacional Natural Tayrona. Get ready for a full day of sightseeing on the 7th (Wed): take your sightseeing to a higher altitude at Sierra Nevada de Santa Marta and then head outdoors with Pozo Azul.

To plan Tayrona National Park vacation without wasting time, ask Inspirock to design an itinerary.

You can fly from Bogota to Tayrona National Park in 4 hours. Alternatively, you can drive; or do a combination of bus and taxi. In October, Tayrona National Park is warmer than Bogota - with highs of °F and lows of °F. Cap off your sightseeing on the 7th (Wed) early enough to go by car to Cartagena.

Things to do in Tayrona National Park

Nature Parks Outdoors

Side Trip

Minca
Find places to stay Oct 5 — 7:
Highlights from your plan
Parque Nacional Natural Tayrona ©
Parque Nacional Natural Tayrona
Sierra Nevada de Santa Marta
Sierra Nevada de Santa Marta
Pozo Azul ©
Pozo Azul

2
nights
Cartagena, Colombia

Cartagena ©
The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.
On the 8th (Thu), examine the collection at Choco Museo, steep yourself in history at Plaza Santo Domingo, explore the historical opulence of Castillo de San Felipe de Barajas, thentake in the spiritual surroundings of Convent of Santa Cruz de la Popa, and finally appreciate the history behind Monumento a Los Zapatos Viejos. On the next day, take in the architecture and atmosphere at Sanctuary of Saint Peter Claver, get a new perspective on things with Boat Tours & Water Sports, and then steep yourself in history at Walled City of Cartagena.

To see ratings, more things to do, and tourist information, go to the Cartagena trip itinerary tool.

You can drive from Tayrona National Park to Cartagena in 4 hours. Another option is to take a bus. In October in Cartagena, expect temperatures between °F during the day and °F at night. Wrap up your sightseeing on the 9th (Fri) early enough to travel to Margarita Island.

Things to do in Cartagena

Historic Sites Tours Outdoors
Find places to stay Oct 7 — 9:
Highlights from your plan
Walled City of Cartagena ©
Walled City of Cartagena
Castillo de San Felipe de Barajas ©
Castillo de San Felipe de Barajas
Plaza Santo Domingo ©
Plaza Santo Domingo

6
nights
Margarita Island, Venezuela

Margarita Island
A popular holiday spot for Venezuelans, sunny Margarita Island boasts an exotic Caribbean location, but at the same time is easily accessible from the mainland.
Do some cultural sightseeing at Fortín La Galera and Hacienda El Tanque. Get some historical perspective at Basilica Nuestra Senora Del Valle and Castillo de Santa Rosa. Spend the 12th (Mon) exploring nature at Laguna de la Restinga. There's still lots to do: enjoy the sand and surf at Playa Parguito, let the kids burn off some steam at Parque Plaza Aventura, head outdoors with Playa Caribe, and get a new perspective on things with Boat Tours & Water Sports.

For maps, more things to do, reviews, and other tourist information, read Margarita Island attractions planner.

You can fly from Cartagena to Margarita Island in 9 hours. Another option is to do a combination of car and ferry. The time zone difference when traveling from Cartagena to Margarita Island is 1 hour. October in Margarita Island sees daily highs of °F and lows of °F at night. Finish your sightseeing early on the 16th (Fri) so you can travel to Coro.

Things to do in Margarita Island

Parks Outdoors Beaches
Find places to stay Oct 9 — 16:
Highlights from your plan
Playa el Yaque
Playa el Yaque
Laguna de la Restinga ©
Laguna de la Restinga
Fortín La Galera
Fortín La Galera

3
nights
Coro, Venezuela

Coro ©
The oldest city in western Venezuela, Coro was founded in 1527 and possesses a rich, varied cultural heritage.
Popular historic sites such as Plaza San Clemente and Catedral Basilica de Santa Ana de Coro are in your itinerary. Get some cultural insight at Medanos de Coro and Old Customs of La Vela de Coro. And it doesn't end there: head outdoors with Cataratas de Hueque, don't miss a visit to Juan de Ampies Square, pause for some serene contemplation at Iglesia San Francisco, and see the interesting displays at Casa De Las Ventanas De Hierro.

To find other places to visit, photos, and other tourist information, use the Coro day trip website.

You can do a combination of flight and taxi from Margarita Island to Coro in 7.5 hours. Alternatively, you can do a combination of car and ferry; or do a combination of taxi, ferry, and bus. October in Coro sees daily highs of °F and lows of °F at night. Finish your sightseeing early on the 19th (Mon) to allow enough time to travel to Caracas.

Things to do in Coro

Historic Sites Outdoors Museums
Find places to stay Oct 16 — 19:
Highlights from your plan
Iglesia San Francisco ©
Iglesia San Francisco
Medanos de Coro ©
Medanos de Coro
Plaza San Clemente ©
Plaza San Clemente

2
nights
Caracas, Venezuela

Caracas ©
Tropical weather, great food, and memorable jungle surroundings seem like all the ingredients Caracas needs to become a must-see destination.
Start off your visit on the 20th (Tue): take in the architecture and atmosphere at Iglesia Nuestra Senora de Las Mercedes, thenbrowse the exhibits of Casa Natal & Museo Bolivar, and then get outside with Parque Nacional el Avila. Keep things going the next day: explore the world behind art at Hacienda La Trinidad Parque Cultural, thenadmire the landmark architecture of Ciudad Universitaria de Caracas, and then take in the architecture and atmosphere at Iglesia Sagrado Corazon de Jesus.

To find maps, traveler tips, where to stay, and other tourist information, read our Caracas road trip planner.

Getting from Coro to Caracas by flight takes about 4.5 hours. Other options: drive; or take a bus. Wrap up your sightseeing on the 21st (Wed) early enough to travel to Arequipa.

Things to do in Caracas

Outdoors Museums Historic Sites
Find places to stay Oct 19 — 21:
Highlights from your plan
Parque Nacional el Avila ©
Parque Nacional el Avila
Casa Natal & Museo Bolivar ©
Casa Natal & Museo Bolivar
Hacienda La Trinidad Parque Cultural ©
Hacienda La Trinidad Parque Cultural

2
nights
Arequipa, Peru

Arequipa ©
In an area dominated three imposing volcanoes, Arequipa vacations allow visitors to admire well-preserved colonial architecture in a dramatic setting.
On the 22nd (Thu), look for gifts at La Iberica, contemplate the long history of Historic Centre of Arequipa, see the interesting displays at Santa Catalina Monastery, thenget engrossed in the history at Museo Santuarios Andinos, and finally appreciate the extensive heritage of Iglesia de la Compania de Jesus. Keep things going the next day: contemplate the geological forces at Volcan Misti, thentake in the architecture and atmosphere at Museo de la Catedral de Arequipa, and then get out on two wheels at MotoAndes.

For photos, traveler tips, reviews, and more tourist information, read Arequipa road trip planner.

Traveling by flight from Caracas to Arequipa takes 11 hours. Alternatively, you can drive; or do a combination of bus and car. The time zone difference moving from Venezuela Time (VET) to Peru Standard Time (PET) is minus 1 hour. In October, plan for daily highs up to °F, and evening lows to °F. Finish your sightseeing early on the 23rd (Fri) to allow enough time to travel to Maras.

Things to do in Arequipa

Historic Sites Museums Parks
Find places to stay Oct 21 — 23:
Highlights from your plan
Historic Centre of Arequipa ©
Historic Centre of Arequipa
Santa Catalina Monastery ©
Santa Catalina Monastery
Museo Santuarios Andinos ©
Museo Santuarios Andinos

2
nights
Maras, Peru

Maras ©
Maras is a town in the Sacred Valley of the Incas, 40 kilometers north of Cuzco, in the Cuzco Region of Peru. On the 24th (Sat), delve into the distant past at Moray and then contemplate the long history of Salinas de Maras. Here are some ideas for day two: see the interesting displays at Yucay Museo de Cultura Viva, hike along Urubamba Weavers' Route, and then don't miss a visit to Iglesia San Martin de Tours.

To find more things to do, where to stay, other places to visit, and more tourist information, use the Maras online driving holiday planner.

Getting from Arequipa to Maras by flight takes about 4 hours. Other options: drive; or do a combination of bus and taxi. Traveling from Arequipa in October, plan for a bit cooler nights in Maras, with lows around °F. Finish your sightseeing early on the 25th (Sun) to allow enough time to travel to Machu Picchu.

Things to do in Maras

Historic Sites Parks Outdoors

Side Trips

Urubamba Weavers' Route, Iglesia San Martin de Tours, Yucay Museo de Cultura Viva
Find places to stay Oct 23 — 25:
Highlights from your plan
Salinas de Maras ©
Salinas de Maras
Moray ©
Moray
Urubamba Weavers' Route ©
Urubamba Weavers' Route

2
nights
Machu Picchu, Peru

Machu Picchu ©
A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
Kick off your visit on the 26th (Mon): steep yourself in history at Santuario Historico de Machu Picchu and then get to know the resident critters at Mariposario de Machupicchu. On the next day, don't miss a visit to Plaza Manco Capac, take in the architecture and atmosphere at Iglesia Virgen Del Carmen, thenwitness a stunning natural landmark at Hot Springs (Aguas Calientes), and finally take some stellar pictures from Intipuncu.

For ratings, maps, other places to visit, and more tourist information, refer to the Machu Picchu road trip tool.

You can do a combination of taxi and train from Maras to Machu Picchu in 3 hours. Alternatively, you can drive. Wrap up your sightseeing on the 27th (Tue) early enough to travel to Cusco.

Things to do in Machu Picchu

Historic Sites Parks Nature
Find places to stay Oct 25 — 27:
Highlights from your plan
Santuario Historico de Machu Picchu ©
Santuario Historico de Machu Picchu
Intipuncu ©
Intipuncu
Hot Springs (Aguas Calientes) ©
Hot Springs (Aguas Calientes)

2
nights
Cusco, Peru

Cusco ©
Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Kick off your visit on the 28th (Wed): get outside with Outdoor Activities and then steep yourself in history at Sacsayhuaman. On the next day, contemplate in the serene atmosphere at Qorikancha, view the masterpieces at Xapiri, thentrek along exploor, thencontemplate the long history of Plaza de Armas, and finally explore the world behind art at Museo de Arte Precolombino.

To find ratings, maps, and other tourist information, go to the Cusco trip itinerary maker app.

Traveling by combination of train and bus from Machu Picchu to Cusco takes 4 hours. Alternatively, you can take a train; or drive. Expect a daytime high around °F in October, and nighttime lows around °F. Finish up your sightseeing early on the 29th (Thu) so you can travel to Lima.

Things to do in Cusco

Historic Sites Outdoors Tours
Find places to stay Oct 27 — 29:
Highlights from your plan
Sacsayhuaman ©
Sacsayhuaman
Qorikancha ©
Qorikancha
Plaza de Armas ©
Plaza de Armas

2
nights
Lima, Peru

Lima ©
Founded in 1535 by Spanish explorer Francisco Pizarro, Lima represents an interesting blend of modern attractions and preserved colonial architecture, much of it clustered in the World Heritage-listed city center.
Start off your visit on the 30th (Fri): wander the streets of Miraflores, contemplate the long history of Huaca Pucllana, thentake an in-depth tour of Museo Convento San Francisco y Catacumbas, and finally get to know the fascinating history of Centro Historico de Lima. Get ready for a full day of sightseeing on the 31st (Sat): ponder the design of Plaza de Armas (Plaza Mayor) and then get engrossed in the history at Museo Larco.

To see photos, other places to visit, and more tourist information, you can read our Lima trip itinerary builder app.

Getting from Cusco to Lima by flight takes about 3.5 hours. Other options: drive; or take a bus. Traveling from Cusco in October, you can expect nighttime temperatures to be somewhat warmer in Lima, with lows of °F. Finish your sightseeing early on the 31st (Sat) so you can travel to Cuenca.

Things to do in Lima

Historic Sites Museums Neighborhoods
Find places to stay Oct 29 — 31:
Highlights from your plan
Huaca Pucllana ©
Huaca Pucllana
Museo Convento San Francisco y Catacumbas ©
Museo Larco ©
Museo Larco

2
nights
Cuenca, Ecuador

Cuenca ©
Packed with impressive colonial architecture and a historic town center, Cuenca stands as perhaps the most charming city in the nation.
Start off your visit on the 1st (Sun): get engrossed in the history at Pumapungo Museum and Arqueological Park - MCYP, explore the wealth of natural beauty at El Cajas National Park, thencontemplate the waterfront views at Rio Tomebamba, and finally view the masterpieces at Homero Ortega. Get ready for a full day of sightseeing on the 2nd (Mon): take in the spiritual surroundings of Museo Catedral Vieja, admire the landmark architecture of Inmaculada Concepción Cathedral, steep yourself in history at Plaza de las flores, thenpause for some serene contemplation at Mirador de Turi, and finally trot along with a tour on horseback.

To find reviews, ratings, photos, and more tourist information, you can read our Cuenca route planner.

Fly from Lima to Cuenca in 7 hours. Alternatively, you can drive; or take a bus. Traveling from Lima in October, Cuenca is little chillier at night with lows of °F. Finish your sightseeing early on the 2nd (Mon) so you can travel to Quito.

Things to do in Cuenca

Historic Sites Museums Nature
Find places to stay Oct 31 — Nov 2:
Highlights from your plan
Mirador de Turi ©
Mirador de Turi
El Cajas National Park ©
El Cajas National Park
Museo Catedral Vieja ©
Museo Catedral Vieja

2
nights
Quito, Ecuador

Quito ©
High in the Andean foothills, Quito remains one of the world's most photogenic capital cities, featuring two dramatic mountain ranges as its backdrop.
Start off your visit on the 3rd (Tue): take in the spiritual surroundings of Basilica del Voto Nacional, thentake in the architecture and atmosphere at Iglesia y Convento de San Francisco, thenadmire the striking features of Fundacion Iglesia de la Compania, and finally get to know the fascinating history of Quito Old Town. On your second day here, take an in-depth tour of Museo Templo del Sol Pintor Ortega Maila, don't miss a visit to Mitad Del Mundo, and then contemplate the geological forces at Rucu Pichincha.

For where to stay, traveler tips, maps, and more tourist information, refer to the Quito journey builder.

Traveling by flight from Cuenca to Quito takes 3.5 hours. Alternatively, you can drive; or take a bus. Expect a bit warmer evenings in Quito when traveling from Cuenca in November, with lows around °F. Finish up your sightseeing early on the 4th (Wed) so you can travel to Puerto Villamil.

Things to do in Quito

Historic Sites Nature Parks
Find places to stay Nov 2 — 4:
Highlights from your plan
Museo Templo del Sol Pintor Ortega Maila ©
Museo Templo del Sol Pintor Ortega Maila
Fundacion Iglesia de la Compania ©
Fundacion Iglesia de la Compania
Iglesia y Convento de San Francisco ©
Iglesia y Convento de San Francisco

2
nights
Puerto Villamil, Ecuador

Puerto Villamil ©
Located in the southeast of Isla Isabela, Puerto Villamil is home to the majority of the island's 2,200 inhabitants.
Kick off your visit on the 5th (Thu): stroll through Posada de flamengos, explore the activities along Laguna Salinas, thenget outside with Outdoor Activities, and finally tour the pleasant surroundings at Concha de Perla. Keep things going the next day: explore the activities along Laguna de los Diablos, take in the dramatic natural features at El Tunel del Estero, thenkick back and relax at Playa Puerto Villamil, thenhead off the coast to Las Tintoreras, and finally pause for some serene contemplation at Iglesia Cristo Salvador.

To see traveler tips, other places to visit, more things to do, and more tourist information, go to the Puerto Villamil trip planner.

Fly from Quito to Puerto Villamil in 6.5 hours. Due to the time zone difference, you'll gain 1 hour traveling from Quito to Puerto Villamil. Finish your sightseeing early on the 6th (Fri) so you can ride a ferry to Puerto Ayora.

Things to do in Puerto Villamil

Parks Outdoors Nature
Find places to stay Nov 4 — 6:
Highlights from your plan
Concha de Perla ©
Concha de Perla
Stand-Up Paddleboarding
Iglesia Cristo Salvador ©
Iglesia Cristo Salvador

3
nights
Puerto Ayora, Ecuador

Puerto Ayora ©
The largest settlement in the Galapagos, Puerto Ayora offers visitors to the islands an array of facilities and things to do.
On the 7th (Sat), take an in-depth tour of Maprae, explore the world behind art at Galeria Exotico Ecuador, get a taste of the local shopping with Maki-Art Gallery, thenget a taste of the local shopping with The Angelique Art Gallery, thendon't miss a visit to Monumento de aves de Galapagos, and finally enjoy the sand and surf at Galapagos Beach at Tortuga Bay. On the 8th (Sun), you'll have a packed day of sightseeing: view the masterpieces at Galeria Aymara, thentake in the dramatic natural features at Las Grietas, and then stroll through Charles Darwin Research Station.

For where to stay, more things to do, photos, and tourist information, you can read our Puerto Ayora road trip planner.

Ride a ferry from Puerto Villamil to Puerto Ayora in 3.5 hours. Due to the time zone difference, you'll lose 1 hour traveling from Puerto Villamil to Puerto Ayora. Expect a daytime high around °F in November, and nighttime lows around °F. Finish your sightseeing early on the 9th (Mon) so you can ride a ferry to Puerto Baquerizo Moreno.

Things to do in Puerto Ayora

Parks Museums Shopping

Side Trip

Santa Cruz
Find places to stay Nov 6 — 9:
Highlights from your plan
Galapagos Beach at Tortuga Bay ©
Galapagos Beach at Tortuga Bay
Charles Darwin Research Station ©
Charles Darwin Research Station
Galeria Aymara ©
Galeria Aymara

1
night
Puerto Baquerizo Moreno, Ecuador

Puerto Baquerizo Moreno ©
The capital of the Galapagos Islands, Puerto Baquerizo Moreno is located on easternmost island of the archipelago, San Cristobal.
On the 9th (Mon), learn more about the world around you at Interpretation Center, explore the striking landscape of Cerro Tijeretas, and then pause for some photo ops at Estatua de Charles Darwin. Keep things going the next day: take in the architecture and atmosphere at Catedral Inmaculada Concepcion, make a trip to La Casa del Ceibo, thentour the pleasant surroundings at La Loberia, and finally enjoy the sand and surf at Playa de Oro.

For where to stay, maps, and tourist information, go to the Puerto Baquerizo Moreno trip planner.

You can ride a ferry from Puerto Ayora to Puerto Baquerizo Moreno in 3.5 hours. In November in Puerto Baquerizo Moreno, expect temperatures between °F during the day and °F at night. Finish your sightseeing early on the 10th (Tue) to allow enough time to travel back home.

Things to do in Puerto Baquerizo Moreno

Parks Nature Wildlife

Side Trip

San Cristobal
Find places to stay Nov 9 — 10:
Highlights from your plan
Cerro Tijeretas ©
Cerro Tijeretas
Interpretation Center ©
Interpretation Center
Catedral Inmaculada Concepcion ©
Catedral Inmaculada Concepcion

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